Comparative Analysis of Bone Mechanical Properties of Adipose-Derived Mesenchymal Stem Cells and Raloxifene in Treatment of Osteoporosis

作者：Chengdong Piao; Zhengwei Li; Jie Ding; Daliang Kong

来源：Journal of Hard Tissue Biology, 2020, 29(2): 71-76.

DOI：10.2485/jhtb.29.71

• Osteoporotic animal model
• Adipose-derived mesenchymal stem cells
• Density bone
• Histomorphometry index
• Compression
• Shock
• Biomechanics

This study aims to compare the bone mechanical properties of adipose-derived mesenchymal stem cells (ADMSCs) and raloxifene in treating osteoporosis and to provide related biomechanical basis. The serum of animal model of osteoporosis was sampled after ADMSCs or raloxifene intervention and measured BALP, TRACP -5b, MMP -9, and Cath-K the femur was taken for compression test, tibia for shock test, vertebrae for bone mineral densitytest, humerus for histomorphometric index test. In Group AMSCs, BMD and BALP were higher than those in Group MOD, in Group RAL, TRACP-5b, MMP-9 mL-1 and Cath-K were lower than those in Group MOD with significant differences (p \n