Hedychins E and F: Labdane-Type Norditerpenoids with Anti- Inflammatory Activity from the Rhizomes of Hedychium forrestii

作者：Zhao, Qing; Xiao, Long-Gao; Bi, Li-Sha; Si, Yu; Zhang, Xiao-Mei; Chen, Jian-Hong^*; Liu, Hai-Yang^*

来源：Organic Letters, 2022, 24(38): 6936-6939.

DOI：10.1021/acs.orglett.2c02710

• DITERPENOIDS
• ANTIOXIDANT
• CORONARIUM
• CYTOKINES

Hedychin E (1), a novel labdane-type norditerpenoid, and hedychin F (2), a new labdane-type dinorditerpenoid, were isolated from the rhizomes of Hedychium forrestii. Their structures were determined through a combination of spectroscopic analysis and X-ray single-crystal diffractions. Hedychin E (1) is an unprecedented 6-norditerpenoid with a fused tetrahydrofuran-lactone motif, and a reasonable biosynthetic pathway for 1 was proposed. Compound 2 showed a significant anti-inflammatory effect against LPS-induced NO production in macrophage RAW264.7 cells with an IC50 value of 21.0 mu M.

• 单位
  云南大学; 中国科学院研究生院