Clinical expert consensus on the assessment and protection of pancreatic islet ll-cell function in type 2 diabetes mellitus

摘要

Islet ll-cell dysfunction is a basic pathophysiological characteristic of type 2 diabetes mellitus (T2DM). Appro-priate assessment of islet ll-cell function is beneficial to better management of T2DM. Protecting islet ll-cell function is vital to delay the progress of type 2 diabetes mellitus. Therefore, the Pancreatic Islet ll-cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jiangsu Medical Association organized experts to draft the "Clinical expert consensus on the assessment and protection of pancreatic islet fl-cell function in type 2 diabetes mellitus." This consensus suggests that 8 -cell function can be clinically assessed using blood glucose -based methods or methods that combine blood glucose and endogenous insulin or C-peptide levels. Some measures, including weight loss and early and sustained euglycemia control, could effectively protect islet 8 -cell function, and some newly developed drugs, such as Sodium-glucose cotransporter-2 inhibitor and Glucagon-like peptide-1 receptor agonists, could improve islet 8 -cell function, independent of glycemic control.

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