Engineering the Redox-Driven Channel for Precisely Regulating Nanoconfined Glutathione Identification and Transport

作者：Guan, Tianpei; Cheng, Ming; Zeng, Lisi; Chen, Xiaoya; Xie, Yuan; Lei, Ziying; Ruan, Qiang; Wang, Jin^*; Cui, Shuzhong^*; Sun, Yao^*; Li, Haibing^*

来源：ACS applied materials & interfaces, 2021, 13(41): 49137-49145.

DOI：10.1021/acsami.1c12061

• artificial intelligent nanochannel
• selective transport
• host-guest
• glutathione
• redox-regulated switch

Bioinspired artificial nanochannels for molecular and ionic transport have extensive applications. However, it is still a huge challenge to achieve an intelligent transport system with high selectivity/efficiency and controllability. Inspired by glutathione transport across the plasma membrane via redox regulation, we herein designed and fabricated a redox-reactive artificial nanochannel based on the host-guest chemical strategy. The nanochannel platform achieved high selectivity/efficiency for the identification and transmission of glutathione in the confined space. In addition, this nanochannel can switch between the ON and OFF states through the redox reaction. This redox-regulated system can provide a potential application for detection/binding of biological analytes and redox-controlled drug release.

• 单位
  y; 广州医学院