科研之友
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摘要
To thrive in nature, bacteria have to reproduce efficiently under favorable conditions and persist during stress. The global strategy that integrates the growth control and stress response remains to be explored. stress tolerance of E. coli, resulting from a global resource re-allocation from ribosome synthesis to the of alanine and arginine, facilitating the adaption of bacteria to nutrient downshift. Our work demonstrates ppGpp enables bacteria to integrate the control of growth and stress response in a seesaw fashion, thus acting as an important global regulator of the bacterial fitness landscape.
