Anti-neuroinflammatory 3-hydroxycoumaronochromones and isoflavanones enantiomers from the fruits of Ficus altissima Blume

作者：Yao, Jiaming; Qin, Qiuyi; Wang, Yihai^*; Zeng, Jia; Xu, Jingwen; He, Xiangjiu^*

来源：Phytochemistry, 2022, 202: 113313.

DOI：10.1016/j.phytochem.2022.113313

• Ficus altissima
• Moraceae
• Structural elucidation
• Coumaronochromones
• Isoflavanones
• Anti-neuroinflammatory

A phytochemical study on the fruits of Ficus altissima Blume (lofty fig) led to the isolation and structural elucidation of three pairs of enantiomeric 3-hydroxycoumaronochromones and two pairs of enantiomeric isoflavanones, including eight undescribed compounds. Their structures were determined based on a comprehensive analysis of NMR and HR-ESI-MS spectroscopic data, calculated C-13 NMR-DP4 plus analysis and the comparisons of experimental measurements of ECD with calculated ECD spectra by TDDFT or ECD plots in reported protocols. The inhibitory effects of the isolated enantiomers on NO production stimulated by LPS in microglial BV-2 cells were evaluated. Among them, ficusaltin D exhibited the most potent anti-neuroinflammatory activity, which inhibited the production of NO and the expression of iNOS, IL-6 and IL-1 beta and suppressed the NF-kappa B nuclear translocation in LPS-induced BV-2 cells, while its enantiomer displayed cytotoxicity.

• 单位
  y; 广东药学院