Multiparametric cardiovascular magnetic resonance characteristics and dynamic changes in asymptomatic heart-transplanted patients

作者：Yang, Yuelong; Li, Tingyu; Zhou, Xiaobing; Tan, Zekun; Chen, Rui; Xiao, Zebin; Li, Xiaodan; Luo, Wei; Xu, Huanwen; Ye, Weitao; Liu, Entao; Wu, Zhigang; Wu, Min^*; Liu, Hui^*

来源：European Radiology, 2023, 33(7): 4600-4610.

DOI：10.1007/s00330-022-09358-2

• Cardiovascular magnetic resonance
• Heart transplantation
• Tissue characteristics
• Follow-up

Objectives To describe the dynamic changes in cardiac deformation and tissue characteristics using cardiac magnetic resonance (CMR) in asymptomatic patients during 12 months after heart transplantation (HT). Methods From April 2020 to January 2021, 21 consecutive HT patients without clinical symptoms were included in this prospective study. Multiparametric CMR was performed at 3, 6, and 12 months after HT. Twenty-five healthy volunteers served as controls. Results During follow-up, a decline in left ventricular (LV) global radial strain (GRS) (p = 0.020) and right ventricular (RV) global longitudinal strain (GLS) (p < 0.001) and an increase in post-contrast T1 (p = 0.024) and T2 (p < 0.001) in asymptomatic HT patients occurred at 3 months, which normalized at 6 months postoperatively, compared with those in healthy controls. A decline in LVGLS (p < 0.001) and LV global circumferential strain (GCS) (p < 0.001) and an increase in native T1 (p < 0.001), T2 (p < 0.001), and extracellular volume (ECV) (p < 0.001) occurred at 3 months. Although most parameters improved gradually, LVGLS, native T1, and ECV remained abnormal compared with those in healthy controls at 12 months; only T2 and LVGCS were normalized at 6 months and 12 months, respectively. ECV was significantly correlated with LVGLS, LVGCS, and LVGRS. Conclusion Cardiac deformation and tissue characteristics were abnormal early after HT, although the patients were clinically asymptomatic. The dynamic changes in CMR characteristics demonstrate a gradual recovery of myocardial injury associated with transplantation during the first 12 months after HT.

• 单位
  Guangdong Provincial Cardiovascular Institute; Southern Medical University; Guangdong General Hospital; 5; Sun Yat-sen University