B(C6F5)3-Catalyzed Hydroarylation of Terminal Alkynes with Phenols

摘要

We developed a B(C6F5)(3) catalyzed hydroarylation of terminal alkynes with various phenols at room temperature without adding any additives, leading to the synthesis of 2-gem-vinylphenols with good regio-selectivity. Those transformations featured a broad substrate scope with moderate yields. Mechanism studies indicated that those transformations proceeded through the activation of phenol by B(C6F5)(3) with subsequent protonation of alkyne/Friedel-Crafts-type reaction.

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