Towards population-specific pharmacogenomics in the era of next-generation sequencing

作者：Ji, Xiangjun; Ning, Baitang; Liu, Jinghua; Roberts, Ruth; Lesko, Larry; Tong, Weida^*; Liu, Zhichao^*; Shi, Tieliu^*

来源：Drug Discovery Today, 2021, 26(8): 1776-1783.

DOI：10.1016/j.drudis.2021.04.015

• Pharmacogenomics
• Next-generation sequencing
• Population group
• Biomarkers

Pharmacogenomics (PGx) has essential roles in identifying optimal drug responders, optimizing dosage regimens and avoiding adverse events. Population-specific therapeutic interventions that tackle the genetic root causes of clinical outcomes are an important precision medicine strategy. In this perspective, we discuss next-generation sequencing genotyping and its significance for population specific PGx applications. We emphasize the potential of NGS for preemptive pharmacogenotyping, which is crucial to population-specific clinical studies and patient care. We also provide examples that use publicly available population-based genomics data for population-specific PGx studies. Last, we discuss the remaining challenges and regulatory efforts towards improvements in this field.

• 单位
  南方医科大学