Electrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction

摘要

An efficient electrochemical synthesis of 1,2,3-trisubstituted pyrroles was developed by one-pot three-component reaction of beta-dicarbonyl compounds, aldehydes with amines. The target products could be obtained in good to excellent yields. Our investigations indicate that beta-enamino ketone is a key intermediate in this transformation and the reaction mechanism may involve a radical addition reaction pathway.

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