Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity

作者：Chen, Zhongxin; Liu, Cuibo; Liu, Jia; Li, Jing; Xi, Shibo; Chi, Xiao; Xu, Haisen; Park, In-Hyeok; Peng, Xinwen; Li, Xing; Yu, Wei; Liu, Xiaowang; Zhong, Linxin; Leng, Kai; Huang, Wei; Koh, Ming Joo^*; Loh, Kian Ping^*

来源：Advanced Materials, 2020, 32(4): 1906437.

DOI：10.1002/adma.201906437

• chemoselective transformation
• electrochemical intercalation
• organic catalysis
• single-atom materials
• transition metal dichalcogenides

The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co-1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal-substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.

• 单位
  天津大学; 西北工业大学; 1