Indazolones Directed Rh(III)-Catalyzed C-H Amidation of Arenes

作者：Chen, Shao-Yong; Zheng, Yi-Chuan; Liu, Xu-Ge^*; Song, Jia-Lin; Shu, Bing; Zheng, Tao; Xiao, Lin; Zhang, Shang-Shi^*; Cao, Hua^*

来源：Advanced Synthesis and Catalysis, 2022, 364(18): 3302-3309.

DOI：10.1002/adsc.202200570

• Indazolones
• Rh(III)-Catalyzed
• C-H activation
• Amidation

The Cp*Rh(III)-catalyzed indazolone-directed C-H bond amidation of arenes has been realized by employing sulfonyl azide agents and dioxazolones as nitrogen source. This protocol displays mild conditions, broad substrate scope and high functional group compatibility. What' more, the late-stage modifications of structure complicated drugs, such as Gemfibrozil, Oxaprozin, Probenecid and Naproxen, has been demonstrated. Furthermore, preliminary mechanistic investigation and an exploratory reaction mechanism were also proposed.

• 单位
  广东药学院