The Escherichia coli Mismatch Repair Protein MutL Recruits the Vsr and MutH Endonucleases in Response to DNA Damage

作者：Polosina, Yaroslava Y.; Mui, Justin; Pitsikas, Photini; Cupples, Claire G.^*

来源：Journal of Bacteriology, 2009, 191(12): 4041-4043.

DOI：10.1128/JB.00066-09

• SHORT-PATCH REPAIR
• FUNCTIONAL INTERACTIONS
• OVEREXPRESSION
• TRANSVERSIONS
• MUTATIONS
• ABUNDANCE
• SYSTEM
• GENOME

The activities of the Vsr and MutH endonucleases of Escherichia coli are stimulated by MutL. The interaction of MutL with each enzyme is enhanced in vivo by 2-aminopurine treatment and by inactivation of the mutY gene. We hypothesize that MutL recruits the endonucleases to sites of DNA damage.