Base-Catalyzed One-Pot Synthesis of 2,3,6-Substituted Pyridines

作者：Zhu, Baofu^*; He, Jiaming; Zou, Kai; Li, Anquan; Zhang, Chen; Zhao, Jiaji; Cao, Hua^*

来源：Journal of Organic Chemistry, 2023, 88(16): 11450-11459.

DOI：10.1021/acs.joc.3c00375

• MULTICOMPONENT REACTION
• GOLD CATALYSIS
• ISOCYANIDES
• AMINES
• DERIVATIVES

A three-component reaction catalyzed by base was established,whichmainly consisted of ynals, isocyanates, amines and alcohols. Thisstrategy provides a wide range of substrates and represents a simpleprocess for the preparation of different pyridine derivatives in goodyields with high regioselectivities.

• 单位
  广东药学院