10 Gram-scale synthesis of TY-Phos ligand and its application in carbene insertion of Si-H bonds

作者：Zhang, Yaochen; Pan, Zhangjin; Guo, Hao^*; Yang, Junfeng^*; Zhang, Junliang^*

来源：2022, 107: 154120.

DOI：10.1016/j.tetlet.2022.154120

• Sadphos
• TY-Phos
• Asymmetric catalysis
• Chiral ligand
• Carbene insertion

The design of chiral ligands has always been one of the most prominent research areas in asymmetric catalysis. This method reports on the 10 g-scale synthesis of one class of Sadphos: TY-Phos ligand. The ligand preparation could be carried out on a scale of 10 g with a reasonable yield, and the preliminary exploration of its application in the enantioselective insertion of carbenes into Si -H bonds is reported.

• 单位
  复旦大学