A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

作者：Zheng, Rongrong; Chen, Xiayun; Zhao, Linping; Yang, Ni; Guan, Runtian; Chen, Ali; Yu, Xiyong; Cheng, Hong^*; Wang, Chang^*; Li, Shiying^*

来源：Chemical Communications, 2021, 57(34): 4134-4137.

DOI：10.1039/d1cc00544h

• THERAPY
• NANOTECHNOLOGY

A porphysome-based photodynamic O-2 economizer (P-PAT) is prepared for hypoxic tumor therapy. The self-assembled porphyrin bilayers of P-PAT possess high loading capacity to atovaquone (ATO) (nearly 70%), which could restrain mitochondrial respiration to relieve hypoxia and enhance photodynamic therapy.

• 单位
  广州医学院; 南方医科大学; 5