The neutrophil-to-lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90-day mortality in non-cirrhotic chronic severe hepatitis

作者：Dong, Fu Chen; Tan, Wen Ting; Wang, Xian Bo; Zheng, Xin; Huang, Yan; Li, Bei Ling; Meng, Zhong Ji; Gao, Yan Hang; Qian, Zhi Ping; Liu, Feng; Lu, Xiao Bo; Shang, Jia; Shi, Yu; Zheng, Yu Bao; Yan, Hua Dong; Zhang, Yan; Xu, Bao Yan; Hou, Yi Xin; Zhang, Qun; Xiong, Yan; Zou, Cong Cong; Chen, Jun; Huang, Ze Bing; Jiang, Xiu Hua; Luo, Sen; Chen, Yuan Yuan; Gao, Na; Liu, Chun Yan; Yuan, Wei; Mei, Xue; Li, Jing; Li, Tao; Zheng, Rong Jiong; Zhou, Xin Yi; Chen, Jin Jun; Deng, Guo Hong; Mei, Xiang Xiao

来源：Journal of Digestive Diseases, 2022, 23(10): 587-596.

DOI：10.1111/1751-2980.13143

• chronic liver disease
• chronic severe hepatitis
• neutrophil-to-lymphocyte ratio
• short-term prognosis
• systemic inflammation

Objectives: To investigate the relationship between systemic inflammatory response and short-term mortality in patients with non-cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil-to-lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet-to lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Methods: Data were collected from two prospectively enrolled CATCH-LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90-day liver transplant (LT)-free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90-day LT-free mortality. Kaplan-Meier method was used to estimate the 90-year LT-free survival. Results: The prevalence of CSH was 20.5% (226/1103). The 28-day and 90-day LT-free mortality rates were 17.7% and 26.1%, respectively, for patients with non-cirrhotic CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90-day LT-free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection. Conclusions: NLR may be an independent risk factor for 90-day LT-free mortality in patients with non-cirrhotic chronic liver disease. A NLR of 2.9 as the cut-off value can be used to predict disease aggravation in CSH patients without infection.

• 单位
  南方医科大学; 1; 吉林大学; 山东大学; 中国科学院研究生院; 华中科技大学; 南开大学; 复旦大学; 上海交通大学; 中山大学; 浙江大学