Preparation and physicochemical properties of coenzyme Q10 loaded niosomal hydrogels based on carbomer and scleroglucan

摘要

In this study, the blank hydrogels and the niosomal hydrogels loading coen-zyme Q10 (CoQ10) were prepared by carbomer (CBM) and scleroglucan (SCL), and their physicochemical properties were characterized in terms of rheologi-cal and texture measurement, FTIR, SEM, DSC, and DLS. First, the blank hydrogels CBM-SCL-Gel were prepared. With the increase of SCL concentra-tion, the viscosity and modulus increased, displaying better shear thinning behavior of pseudoplastic fluid. A dense network structure was formed in CBM-SCL-Gel, especially for CBM/SCL at 5/4 and 5/5, due to hydrogen bond-ing between CBM and SCL. The swelling behaviors of the composite gels con-formed to pseudo-second-order kinetics, and CBM/SCL at 5/1 exhibited the highest swelling capability. The addition of SCL made the water absorption mechanism tend to a non-Fickian diffusion mode. Then, the niosomal hydro-gel was prepared by the optimized gel formulation with the CoQ10-loaded nio-some. It was found that the gel properties were insignificantly affected by the CoQ10 niosomes. The particle sizes of the niosomes in the gel were a little larger than that in aqueous suspension. After storage for 30 days, the CoQ10 retention rate in the niosomal gel remained at 92% (4 degrees C, N-Gel), representing high stability of CoQ10.

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