LOX-1 Regulation in Anti-atherosclerosis of Active Compounds of Herbal Medicine: Current Knowledge and the New Insight

作者:Yao Si-jie; Lan Tao-hua; Zhang Xin-yu; Zeng Qiao-huang; Xu Wen-jing; Li Xiao-qing; Huang Gui-bao; Liu Tong; Lyu Wei-hui; Jiang Wei*
来源:Chinese Journal of Integrative Medicine, 2023, 29(2): 179-185.
DOI:10.1007/s11655-022-3621-9

摘要

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) have recently been identified to be closely related to the occurrence and development of atherosclerosis (AS). A growing body of evidence has suggested Chinese medicine takes unique advantages in preventing and treating AS. In this review, the related research progress of AS and LOX-1 has been summarized. And the anti-AS effects of 10 active components of herbal medicine through LOX-1 regulation have been further reviewed. As a potential biomarker and target for intervention in AS, LOX-1 targeted therapy might provide a promising and novel approach to atherosclerotic prevention and treatment.

  • 单位
    广州中医药大学