TDM-guided medication of polymyxin B in a patient with CRKP-induced bloodstream infection: a case report

作者：Yu, Xuben; Pan, Jingye; Zhou, Ziye; Wen, Xin; Dai, Ying; Lin, Guanyang; Jiao, Zheng; Zhang, Chunhong^*

来源：European Journal of Clinical Microbiology and Infectious Diseases, 2021, 40(1): 201-204.

DOI：10.1007/s10096-020-03945-1

• Polymyxin B
• Acute kidney injury
• Carbapenem-resistantKlebsiella pneumoniae
• Bloodstream infection

The narrow therapeutic window of polymyxin B constrains its clinical use against the multidrug-resistant organisms (MDRO). A 45-year-old patient was suffering with bloodstream infection with high fever and received a combined treatment with polymyxin B and tigecycline. Therapeutic drug monitoring (TDM) was applied to polymyxin B to develop a personalized medication against MDRO. The dose adjustment of polymyxin B with TDM successfully alleviated the infection and reduced the incident of acute kidney injury as caused in case of the original doses of polymyxin B. TDM of polymyxin B represents a valid treatment to ensure the efficiency and safety.

• 单位
  南方医科大学; 1; 上海交通大学