Theta Signal Transfer from Parietal to Prefrontal Cortex Ignites Conscious Awareness of Implicit Knowledge during Sequence Learning

作者：Lu, Yang; Guo, Xiuyan^*; Weng, Xue; Jiang, Haoran; Yan, Huidan; Shen, Xianting; Feng, Zhengning; Zhao, Xinyue; Li, Lin^*; Zheng, Li; Liu, Zhiyuan^*; Men, Weiwei; Gao, Jia-Hong

来源：Journal of Neuroscience, 2023, 43(40): 6760-6778.

DOI：10.1523/JNEUROSCI.2172-22.2023

• brain signal transfer
• conscious awareness
• phase transfer entropy
• sequence learning
• theta oscillation

Unconscious acquisition of sequence structure from experienced events can lead to explicit awareness of the pattern through extended practice. Although the implicit-to-explicit transition has been extensively studied in humans using the serial reaction time (SRT) task, the subtle neural activity supporting this transition remains unclear. Here, we investigated whether frequency-specific neural signal transfer contributes to this transition. A total of 208 participants (107 females) learned a sequence pattern through a multisession SRT task, allowing us to observe the transitions. Session-by-session measures of participants' awareness for sequence knowledge were conducted during the SRT task to identify the session when the transition occurred. By analyzing time course RT data using switchpoint modeling, we identified an increase in learning benefit specifically at the transition session. Electroencephalogram (EEG)/magnetoencephalogram (MEG) recordings revealed increased theta power in parietal (precuneus) regions one session before the transition (pretransition) and a prefrontal (superior frontal gyrus; SFG) one at the transition session. Phase transfer entropy (PTE) analysis confirmed that directional theta transfer from precuneus fi SFG occurred at the pretransition session and its strength positively predicted learning improvement at the subsequent transition session. Furthermore, repetitive transcranial magnetic stimulation (TMS) modulated precuneus theta power and altered transfer strength from precuneus to SFG, resulting in changes in both transition rate and learning benefit at that specific point of transition. Our brain-stimulation evidence supports a role for parietal fi prefrontal theta signal transfer in igniting conscious awareness of implicitly acquired knowledge.

• 单位
  复旦大学; 北京大学