A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

作者：Zeng, Feng; Shi, Yahong; Wu, Chunni; Liang, Jianming; Zhong, Qixin; Briley, Karen; Xu, Bin; Huang, Yongzhuo; Long, Manmei; Wang, Cong; Chen, Jian; Tang, Yonghua; Li, Xinying; Jiang, Mengda; Wang, Luting; Xu, Qin; Yang, Liu; Chen, Peng; Duan, Shengzhong; Xie, Jingyuan^*; Li, Cong^*; Wu, Yingwei^*

来源：JOURNAL OF NANOBIOTECHNOLOGY, 2022, 20(1): 107.

DOI：10.1186/s12951-022-01319-7

• Ceria nanoparticles
• Reactive oxygen species
• Inflammatory bowel disease
• Macrophages
• Proinflammatory microenvironment

Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a lack of effective therapeutic strategies. The proinflammatory microenvironment plays a significant role in both amplifying and sustaining inflammation during IBD progression. Herein, biocompatible drug-free ceria nanoparticles (CeNP-PEG) with regenerable scavenging activities against multiple reactive oxygen species (ROS) were developed. CeNP-PEG exerted therapeutic effect in dextran sulfate sodium (DSS)-induced colitis murine model, evidenced by corrected the disease activity index, restrained colon length shortening, improved intestinal permeability and restored the colonic epithelium disruption. CeNP-PEG ameliorated the proinflammatory microenvironment by persistently scavenging ROS, down-regulating the levels of multiple proinflammatory cytokines, restraining the proinflammatory profile of macrophages and Th1/Th17 response. The underlying mechanism may involve restraining the co-activation of NF-kappa B and JAK2/STAT3 pathways. In summary, this work demonstrates an effective strategy for IBD treatment by ameliorating the self-perpetuating proinflammatory microenvironment, which offers a new avenue in the treatment of inflammationrelated diseases.

• 单位
  上海交通大学; 中国科学院; 广州中医药大学; 1; 复旦大学