Effects of selenylation modification on the antioxidative and immunoregulatory activities of polysaccharides from the pulp of Rose laevigata Michx fruit

作者：Zhan, Qiping; Chen, Yong; Guo, Yifang; Wang, Qian; Wu, Hui^*; Zhao, Liyan^*

来源：International Journal of Biological Macromolecules, 2022, 206: 242-254.

DOI：10.1016/j.ijbiomac.2022.02.149

• Rose laevigata Michx
• Polysaccharide
• Selenylation modification
• Antioxidative activity
• Immunoregulatory activity

Selenylation modification has been widely utilized to improve the activity of polysaccharides and to develop novel sources of selenium (Se) supplements. A purified pulp polysaccharide of Rose laevigata Michx fruit (PPRLMF-2) was selenized into Se-PPRLMF-2 in this study. PPRLMF-2 + Se was formulated by Na2SeO3 according to the Se content of Se-PPRLMF-2. To investigate the effects of selenylation modification on the structure and functions of PPRLMF-2, the characteristics, antioxidative and immunoregulatory activities of PPRLMF-2 before and after selenylation were compared. The results showed that compared with PPRLMF-2, Se-PPRLMF2 became an irregular fibrous network, and its Mw decreased and C-6 substitution predominated in C-13 NMR spectra. Se-PPRLMF-2 significantly increased chemical antioxidant activity and reduced the oxidative damage of erythrocytes, which was not due to Se alone. Se-PPRLMF-2 significantly increased immunomodulatory activity on macrophages, which was related to Se alone. Se-PPRLMF-2 could be a good potential source of antioxidants, immune enhancers and dietary Se supplements.

• 单位
  南京农业大学