Association of gut microbiome and oral cavity cancer: A two sample mendelian randomization and case-control study

作者：Liu, Xinpeng; Li, Xinping; Xie, Menglan; Guo, Jinyuan; Zheng, Xianghuai; Shi, Shanwei; Cui, Qiuju; Zhang, Danya; Zhang, Zhaoqiang^*; Wang, Zhiping^*

来源：Journal of Stomatology Oral and Maxillofacial Surgery, 2024, 125(4): 101736.

DOI：10.1016/j.jormas.2023.101736

• Mendelian randomization
• Oral cavity cancer
• Gut microbiota

Introduction: Considering the interconnectedness of the oral cavity and gut tract and the presence of abundant natural microbiota in both. We utilized Mendelian Randomization (MR) in a two-sample study to unveil the genetic causal impact of gut microbiota on the development of oral cavity cancer.Materials & methods: The instrumental variables employed in this study consisted of single nucleotide polymorphisms (SNPs) that demonstrated a robust association with 211 distinct gut microbiota taxa, encompassing a sample size of 18,340 individuals. Our investigation sought to explore the potential causal relationship between these genetic variants and the incidence of oral cavity cancer. To accomplish this, we adopted a random effect inverse variance-weighted approach to analyze the causal effect. Additionally, sensitivity analyses were performed utilizing Cochran's Q tests, funnel plots, leave-one-out analyses, and MR-Egger intercept tests, to assess the robustness and validity of our findings. Results: Five gut microbiota taxa (the family Prevotellaceae, the genus Alloprevotella, the genus Erysipelatoclostridium, the genus Parabacteroides, the genus Ruminococcus gauvreauii group) are predicted to play a causal role in promoting the initiation of the risk of oral cavity cancer. While the genus Christensenellaceae R 7 group, the genus Intestinimonas, the genus Ruminococcaceae, and the order Bacillales causally reduce the risk of oral cavity cancer. Furthermore, no significant evidence suggesting heterogeneity or pleiotropy was observed.Discussion: The novel genetic causal effects of 211 gut microbiota taxa on oral cavity cancer are elucidated in this investigation, thus offering valuable insights for clinical interventions targeting oral cavity cancer.

• 单位
  南方医科大学