Mechanochemically Induced Dehydrogenation Coupling and [3+2] Cycloaddition of Indolizines with Allenes Using Piezoelectric Materials

作者：Huang, Mingzhou; Deng, Lichan; Lao, Tianfeng; Zhang, Ziwu; Su, Zhengquan; Yu, Yue^*; Cao, Hua^*

来源：Journal of Organic Chemistry, 2022, 87(5): 3265-3275.

DOI：10.1021/acs.joc.1c02940

• STRATEGY

A wide range of indolizines with allenes proceeded smoothly under mechanochemically induced conditions via a [3+2] annulation process, affording various substituted pyrrolo[2,1,5-cd]indolizines in good yields. The reaction efficiency was greatly improved by using piezoelectric material as the charge transfer catalyst. The photophysical properties of the resulting pyrrolo[2,1,5-cd]indolizine were characterized.

• 单位
  y; 广东药学院