MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

作者：Junhong Guan; Changzheng Lu; Qihuang Jin; Huiming Lu; Xiang Chen; Lei Tian; Yanbin Zhang; Janice Ortega; Junqiu Zhang; Silvia Siteni; Mingyi Chen; Liya Gu; Jerry W. Shay; Anthony J. Davis; Zhijian J. Chen; Yang-Xin Fu; Guo-Min Li

来源：Cancer Cell, 2020.

DOI：10.1016/j.ccell.2020.11.004

• mismatch repair
• MLH1
• exonuclease 1
• RPA exhaustion
• Rad51
• cGAS-STING
• cytosolic DNA
• DNA breaks
• chromosome instability

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• 单位
  University of Miami, Miller School of Medicine; University of Texas Southwestern Medical Center; University of Miami Miller School of Medicine