Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer

作者：Jiang Fu-neng; Dai Li-jun; Yang Sheng-bang; Wu Yong-ding; Liang Yu-xiang; Yin Xiao-li; Zou Cui-yun; Zhong Wei-de^*

来源：Pathology Research and Practice, 2020, 216(1): 152732.

DOI：10.1016/j.prp.2019.152732

• FKBP9
• Prostate cancer
• Prognosis

Background: FK506 binding protein 9 (FKBP9) has been reported and identified for a long time, but its relationship with cancer is rarely studied. For example, the role of FK506 binding protein 9 in prostate cancer (PCa) is still unclear. Therefore, we decided to detect the expression level of FKBP9 in PCa and explore its clinical significance. @@@ Methods: The expression level of FKBP9 protein was detected by immunohistochemistry. In addition, it was demonstrated by high-throughput sequencing of mRNA levels in the TCGA (cancer genome atlas) dataset of 499 patients. Kaplan-meier analysis and Cox proportional hazard regression model were used to evaluate the relationship between FKBP9 expression and survival in prostate cancer patients. @@@ Results: The expression of FKBP9 was localized in the cytoplasm, which in normal prostate tissues was obviously lower than that in PCa tissues (P = 0.001). High expression of FKBP9 was related with lymph node metastasis (P = 0.022) and distant metastasis (P = 0.028). Kaplan-Meier survival analysis revealed that the BCR-free survival of PCa patients with high FKBP9 level was significantly shortened (P = 0.041). @@@ Conclusions: FKBP9 may be a cancer promoter that enhances PCa progression, and the level of FKBP9 may be used as an independent precursor of PCa patients.

• 单位
  广州医学院; 1