B(C6F5)3-Catalyzed [2+3]-Cyclative o,m-diC-H Functionalization of Phenols

Authors：Luo, Jingyan; Luo, Zhou; Zhang, Biqi; Zhao, Qiuyu; Liu, Lu; Liu, Yuanyuan^*

Source：Chemistry - A European Journal, 2023, 29(71).

DOI：10.1002/chem.202301595

• B(C6F5)(3)
• C-H functionalization
• [2+3] cyclization
• phenols
• polycyclic compounds

Metal-free catalytic C-H functionalization is highly desired for the construction of C-C bonds. We herein report a highly chemoselective consecutive C-H [2+3]-cyclative functionalization for the simultaneous formation of two C-C bonds with construction of polycyclic phenols catalyzed by commercially available and low-cost B(C6F5)(3). This catalytic system tolerates a wide range of substrate scope, providing a series of 2,6,7,8-tetrahydroacenaphthylen-3-ol-type polycyclic compounds efficiently. Several derivatizations of the catalytic products have also been conducted to show the potential application of this method in synthesis of polycyclic compounds.

• Institution
  上海交通大学