Mexicanolide limonoids from the seeds of Khaya ivorensis with antimicrobial activity

Authors：Xu, Tie; Wang, Zhi-Hai; Zhao, Ying; Sun, De-Rong^*

Source：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023, 25(7): 634-640.

DOI：10.1080/10286020.2022.2133701

• Khaya ivorensis
• Meliaceae
• mexicanolide limonoids
• antimicrobial activity

The methanol extract of the seeds of Khaya ivorensis afforded two new mexicanolide limonoids, ivorensines A and B (1 and 2), together with one known compound, ruageanin D (3). The structures of the isolated compounds were established based on 1 D and 2 D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated limonoids were tested in vitro for antimicrobial potentials against 5 pathogenic microorganisms. As a result, compounds 1-3 exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 50 mu g/ml.

• Institution
  哈尔滨医科大学