Efficacy and safety of baricitinib in patients with severe COVID-19: A systematic review and meta-analysis

作者：Song, Wenxin; Sun, Shishen; Feng, Yilong; Liu, Liujun; Gao, Tianqi; Xian, Shaoxiang^*; Chen, Jie

来源：Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries, 2023, 102(48): e36313.

DOI：10.1097/MD.0000000000036313

• baricitinib
• efficacy
• meta-analysis
• safety
• severe COVID-19

Background:This study aimed to investigate the efficacy and safety of baricitinib in patients with severe coronavirus disease 2019 (COVID-19).Methods:Databases were searched for studies that compared the clinical efficacy and adverse effects of baricitinib with standard therapy for the treatment of severe COVID-19 and clearly reported relevant outcomes published until December 31, 2022. The corresponding data were extracted from these studies. A fixed-effects model was used to calculate the pooled estimates. The study protocol can be accessed at PROSPERO (CRD42023394173).Results:The baricitinib group had a significantly lower mortality rate and proportion of patients who received mechanical ventilation than the control group (OR = 0.61, 0.57; P = .008, 0.02; 95% CI 0.42-0.88; 0.35-0.92; I2 = 71% and 86%, respectively). The length of hospital stay and rates of severe adverse events were not significantly different between the 2 groups.Conclusion:Baricitinib reduces mortality and mechanical ventilation requirements in patients with severe COVID-19. Therefore, we developed a comprehensive understanding of the role of baricitinib in patients with severe COVID-19.

• 单位
  1; 广州中医药大学