One-pot synthesis of chlorhexidine-templated biodegradable mesoporous organosilica nanoantiseptics

作者：He, Yan; Zhang, Yue; Sun, Madi; Yang, Chao^*; Zheng, Xiao; Shi, Chengxin; Chang, Zhimin; Wang, Zheng; Chen, Jinying; Pei, Shuchen; Dong, Wen-fei; Shao, Dan^*; She, Junjun^*

来源：Colloids and Surfaces B: Biointerfaces , 2020, 187: 110653.

DOI：10.1016/j.colsurfb.2019.110653

• Mesoporous organosilica nanoparticles
• Chlorhexidine
• GSH-responsive release
• Antibacterial activity
• Biodegradable

Chlorhexidine (CHX) is a widely used antiseptic in various infection control practices. In this work, we have developed biodegradable mesoporous organosilica nanoparticles (MONs) through a one-pot synthesis by employing CHX as a bifunctional agent that not any acts as a cationic template to form the structure of mesopores but also serves as a broad-spectrum antiseptic. The resulting CHX@MONs exhibit a relatively high CHX content and glutathione (GSH)-responsive release of CHX via a matrix-degradation-controlled mechanism, leading to comparable antibacterial effects with CHX on both Escherichia coli and Staphylococcus aureus. Furthermore, the effective antibacterial concentration of CHX@MONs shows less cytotoxicity toward normal cells. Our findings will help increase the use of CHX as an antiseptic agent, especially for responsive drug release upon bacterial infection.

• 单位
  吉林大学; 1; 西安交通大学; 中国科学院