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摘要
Flaxseed polysaccharide gum (FPG) was extracted through the ultrasound-assisted process using water as a solvent with a yield ranging from 8.05 +/- 0.32% to 12.23 +/- 0.45% by changing different extraction variables. The extracted FPG was analyzed for its functional groups and antioxidant potential. The maximum DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity (approximate to 100%) of FPG was noted at concentrations beyond approximate to 10 mg-ml(-1). The maximum inhibition percentage through ABTS (2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid) (72.4% +/- 1.9%) was noted at 40 mg.ml(-1), which was observed to be less when compared to DPPH at the same concentration. The total antioxidant potential of the FPG solution at a concentration of 10 mg.ml(-1)was equivalent to 461 mg ascorbic acid, which tends to increase with concentration at a much lower scope. The in vivo trial suggested that the least weight gain was noted in experimental groups G(2) and Gh(2). A significant reduction in total cholesterol was noticed in G(1) (-14.14%) and G(2) (-17.72%) and in Gh(1) (-22.02%) and Gh(2) (-34.68%) after 60days of the trial compared to the baseline values. The maximum reduction in total triglyceride was observed in Gh(2) (-25.06%) and Gh(1) (-22.01%) after 60days of the trial. It was an increasing trend in high-density lipoprotein cholesterol (HDL-c) in different experimental groups G(2) (10.51%) than G(1) (5.35%) and Gh(2) (48.96%) and Gh(1) (31.11%), respectively, after 60days of study interval. Reduction of -5.05% and - 9.45% was observed in G(1) and G(2), while similar results were observed in Gh(1) and Gh(2). Conclusively, results suggested a possible protective role of FPG against hyperlipidemia.
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单位佛山科学技术学院
