Xylarcurcosides A-C, three novel isopimarane-type diterpene glycosides from curta YSJ-5

作者：Wei, Shanshan; Chen, Chen; Lai, Jiaying; Zhang, Yanjiang; Nong, Xinmiao; Duan, Fangfang; Wu, Ping; Wang, Sasa^*; Tan, Haibo^*

来源：Carbohydrate Research, 2024, 535: 108987.

DOI：10.1016/j.carres.2023.108987

• Xylaria curta
• Endophytic fungus
• Isopimarane-type diterpene glycosides
• Cytotoxic activity
• Antibacterial activity

Three previously undescribed isopimarane-type diterpene glycosides named as xylarcurcosides A-C (1-3) along with two known ones 16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic acid (4) and hypoxylonoid A (5) were successfully isolated from an ethyl acetate extract of the endophytic fungus Xylaria curta YSJ-5 growing in leaves of Alpinia zerumbet. The spectroscopic methods, electronic circular dichroism (ECD) calculations, and X-ray diffraction experiments were conducted to identify their absolute chemical structures. All these compounds were tested for in vitro cytotoxic, anti-inflammatory, alpha-glucosidase inhibitory, and antibacterial activities. As a result, these novel compounds demonstrated no obvious cytotoxic and antibacterial activity.

• 单位
  中国科学院; 中国科学院研究生院