Hydroxyapatite/chitosan-metformin composite coating enhances the biocompatibility and osteogenic activity of AZ31 magnesium alloy

作者：Li, Hanyang; Qin, Zainen; Ouyang, Yiqiang; Zheng, Bo; Wei, Hong; Ou, Jun^*; Shen, Chong^*

来源：Journal of Alloys and Compounds, 2022, 909: 164694.

DOI：10.1016/j.jallcom.2022.164694

• Magnesium alloy
• Metformin
• Corrosion resistance
• Osteogenesis
• Anti-inflammatory

The rapid degradation rate of degradable magnesium alloys limits their application as orthopaedic implants. To improve the osteogenic activity and corrosion resistance of magnesium alloys, a hydroxyapatite/chitosan-metformin (HA/CS-MF) composite coating was prepared on AZ31 magnesium alloy by hydrothermal treatment. The structure and morphology of the composite coating were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), energy dispersive spectroscopy (EDS), and scanning electron microscopy (SEM). Electrochemical tests and hydrogen evolution experiments were carried out to evaluate the corrosion resistance of the HA/CS-MF composite coating. At the same time, the cytocompatibility, osseointegration ability and anti-inflammatory activity of the HA/CS-MF composite coating were studied. The findings revealed that the HA/CS-MF composite coating exhibits excellent corrosion resistance, biocompatibility and osteogenic activity; can upregulate the expression level of bone-related genes; and is conducive to the polarization of M2 macrophages.

• 单位
  桂林理工大学; 1