Palladium-Catalyzed Tandem Cyclization of Bromoalkynes, Anilines and CO: Access to 1,3-Substituted Maleimides

摘要

A novel palladium-catalyzed three-component carbonylation reaction for the assembly of various 1,3-substituted maleimide derivatives from haloalkynes and simple anilines. The nucleophilic addition reaction of haloalkynes, anilines and CO, and insertion of carbonyl have been achieved sequentially in this reaction. The high chemo- and regioselectivities, as well as no need of expensive ligands or additives further illustrate the synthetic value of this approach. @@@ A novel palladium-catalyzed three-component carbonylation reaction of haloalkynes and anilines for the efficient assembly of 1,3-substituted maleimides has been developed. This approach features high chemo- and regioselectivities and mild reaction conditions.image

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