Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury

作者：Hu, Pan-Pan; Bao, Jing-Fu; Li, Aiqing^*

来源：Metabolism: Clinical and Experimental , 2021, 116: 154435.

DOI：10.1016/j.metabol.2020.154435

• Acute kidney injury
• Fibroblast growth factor-23
• alpha-Klotho

Acute kidney injury is a global disease with high morbidity and mortality. Recent studies have revealed that the fibroblast growth factor-23-alpha-Klotho axis is closely related to chronic kidney disease, and has multiple biological functions beyond bone-mineral metabolism. However, although dysregulation of fibroblast growth factor-23 -alpha-Klotho has been observed in acute kidney injury, the role of fibroblast growth factor-23-alpha-Klotho in the pathophysiology of acute kidney injury remains largely unknown. In this review, we describe recent findings regarding fibroblast growth factor-23-alpha-Klotho, which is mainly involved in inflammation, oxidative stress, and hemodynamic disorders. Further, based on these recent results, we put forth novel insights regarding the relationship between the fibroblast growth factor-23-alpha-Klotho axis and acute kidney injury, which may provide new therapeutic targets for treating acute kidney injury.

• 单位
  南方医科大学