14-3-3 sigma is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer

作者：Li Yi Liang; Liu Lihua; Xiao Yang; Zeng Tao; Zeng Chao^*

来源：Oncology Letters, 2015, 9(1): 290-294.

DOI：10.3892/ol.2014.2676

• 14-3-3 sigma
• prognosis
• apoptosis
• proliferation
• immunohistochemistry

14-3-3 proteins participate in various cellular processes, including apoptosis, proliferation and malignant transformation. 14-3-3 sigma, a member of the 14-3-3 protein family, is important in several types of cancer; however, little is known about the clinical significance and biological roles of 14-3-3 sigma in gastric cancer. The present study analyzed the expression pattern of 14-3-3 sigma in gastric cancer and investigated its correlation with the prognosis of gastric cancer patients. Furthermore, the association of 14-3-3 sigma with Ki-67, Bcl-2 and Bax was evaluated. 14-3-3 sigma was expressed at higher level in gastric cancer tissue compared with healthy gastric tissue, and 14-3-3 sigma expression was significantly correlated with tumor size and tumor node metastasis stage (P<0.05). To the best of our knowledge, the present study data are the first to suggest that 14-3-3 sigma expression has been significantly associated with poor prognosis in gastric cancer. Additionally, 14-3-3 sigma overexpression was positively correlated with Ki-67 and Bcl-2 expression levels. Thus, 14-3-3 sigma is a potential prognostic marker for gastric cancer patients, and may be involved in regulating the apoptosis and proliferation of gastric cancer cells.

• 单位
  广东医学院; 广西医科大学; 南华大学; 1