BRCA1: Beyond double-strand break repair

Authors：Alli E; Ford J M

Source：DNA Repair, 2015, 32: 165-171.

DOI：10.1016/j.dnarep.2015.04.028

• Base-excision repair
• BRCA1

Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.