Chemical constituents of Ajuga forrestii and their anti-ferroptosis activity

作者：Shi, Huiwen; Jiang, Xiufen; Cao, Liudan; Peng, Xing; Tan, Qingyun; Teng, Xifeng; Gu, Qiong^*; He, Lin^*

来源：FITOTERAPIA, 2023, 166: 105461.

DOI：10.1016/j.fitote.2023.105461

• Neoclerodane diterpene
• Anti-ferroptosis activity
• Ajuga
• Forrestii

Six new neoclerodane diterpenoids (1-6), along with ten known compounds (7-16), were isolated from Ajuga forrestii. Their structures were elucidated by HRESIMS, 1D and 2D NMR, ECD calculation, and single-crystal X-ray diffraction analysis. The structure of a known neoclerodane diterpene ajudecunoid C (6) was revised based on the reported NMR empirical rules. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, compounds 8, 9, and 12 significantly inhibited RSL3-induced ferroptosis with EC50 values of 0.45 mu M, 0.076 mu M, and 0.14 mu M.

• 单位
  广东药学院; 中山大学