Trichodermatides A-D, four new polyketides from Trichoderma sp. XM-3

作者：Zhou, Peng; Cao, Jie; Zhu, Hucheng; Chen, Chunmei; Lai, Yongji^*; Zhang, Yonghui^*

来源：FITOTERAPIA, 2023, 169: 105584.

DOI：10.1016/j.fitote.2023.105584

• Trichoderma sp.
• Polyketides
• X-ray diffraction analyses
• Antibacterial activity

Four new polyketides named trichodermatides A-D (1-4), along with five known analogues (5-9), were isolated from the fungus Trichoderma sp. XM-3. Their structures were elucidated on the basis of HRESIMS and NMR analyses, and their absolute configurations were determined by ECD comparison, 1H and 13C NMR calculation, DP4+ analysis, modified Mosher's method, and X-ray crystallography. Trichodermaketone D (9) showed mild antibacterial activity against Pseudomonas aeruginosa.

• 单位
  华中科技大学; 广东药学院