Safety and immunogenicity of a booster dose of the 10-valent pneumococcal nontypeable haemophilus influenzae protein D conjugate vaccine coadministered with DTPW-HBV/HIB and poliovirus vaccines

Authors：Bermal N^*; Szenborn L; Alberto E; Hernandez M; Pejcz J; Majda Stanislawska E; Gatchalian S; Fanic A; Dieussaert I; Schuerman L

Source：Pediatric Infectious Disease Journal, 2011, 30(1): 69-72.

DOI：10.1097/INF.0b013e3181f2da06

• booster vaccination
• immunogenicity
• pneumococcal conjugate vaccine
• safety

The safety and reactogenicity profiles of the 10-valent pneumococcal conjugate vaccine, PHiD-CV, and 7vCRM were comparable within the Philippines and Poland when coadministered as a booster dose with DTPw-HBV/Hib and poliovirus vaccines to toddlers primed with the same vaccines. Robust immune responses for all 10 vaccine pneumococcal serotypes and protein D following PHiD-CV booster vaccination were indicative of effective priming.