Expression of the DNA-repair protein XRCC1 and DNA-repair enzyme Ku70 mRNA in the rat cerebral cortex following global cerebral ischemia/reperfusion Is this correlated with neuroprotective effects of theanine?

作者：Rongliang Xue; Wenchao Chen; Ning Wang; Shasha Li Department of Anesthesiology; Second Affiliated Hospital; Medical College of Xi’an Jiaotong University; Xi’an; Shaanxi Province; China

来源：Neural Regeneration Research, 2010, (01): 41-46.

• brain
• ischemia/reperfusion injury
• XRCC1
• Ku70
• theanine

BACKGROUND: Numerous studies have shown that apoptosis, caused by cerebral ischemia/reperfusion injury, is a dynamic evolving process that occurs in a time-dependent fashion. Non-apoptotic cells can result in apoptosis, with a prolonged reperfusion period and an accumulation of DNA damage. Recent studies have indicated that theanine has a protective effect on the brain. Nonetheless, there is no research relating to whether theanine is neuroprotective following brain injury. OBJECTIVE: To investigate the eff...