Er(OTf)3-catalyzed glycosylation of tertiary/secondary/primary alcohols with peracetylated glucosyl trichloroacetimidate

作者：Liang, Demin; Zhou, Junyi; Li, Deguo; Zhao, Shuanghao; Gu, Wenbo; Liu, Sainan; Wang, Jiale; Wu, Da; Shu, Ruxin^*; Jiang, Liqin^*

来源：2024, 135: 154875.

DOI：10.1016/j.tetlet.2023.154875

• Er(OTf)3
• Glycosylation
• Tertiary Alcohols
• Trichloroacetimidate

Er(OTf)3 was discovered to be an efficient catalyst for glycosylation of tertiary/secondary/primary alcohols with peracetylated alpha-D-glucosyl trichloroacetimidate. 15 Latent fragrant glycosides have been prepared in moderate to excellent yields each on gram scale through Er(OTf)3-catalyzed glycosylation of fragrant alcohols with peracetylated alpha-D-glucosyl trichloroacetimidate at room or 40 degrees C followed by deacetylation with NaOMe, and excellent stereoselectivity was obtained for various alcohol acceptors.