A novel 3,6-diamino-1,8-naphthalimide derivative as a highly selective fluorescent "turn-on" probe for thiols

Authors：Dong Cheng; Zhou Chun Qiong^*; Yang Jian Wei; Liao Ting Cong; Chen Jin Xiang; Yin Cai Xia; Chen Wen Hua

Source：RSC Advances, 2015, 5(42): 32990-32993.

DOI：10.1039/c5ra03849a

A novel 1,8-naphthalimide derivative bearing 3-amino and 6-(2,4-dinitrobenzenesulfonamido) groups was synthesized and found to exhibit a fluorescent "turn-on" response to biothiols, including Cys, Hcy and GSH. This compound exhibited high selectivity and low detection limit, in particular toward Cys. The sensing mechanism involved the cleavage of the 2,4-dinitrobenzenesulfonamido group and the formation of an electron-donating amino group. In addition, its properties for cellular imaging were also briefly discussed.

• Institution
  南方医科大学; 山西大学