An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

作者：Wang, Yongchao; Gong, Ningqiang; Ma, Chi; Zhang, Yuxuan; Tan, Hong; Qing, Guangchao; Zhang, Jimei; Wang, Yufei; Wang, Jinjin; Chen, Shizhu; Li, Xianlei; Ni, Qiankun; Yuan, Yuan; Gan, Yaling; Chen, Junge; Li, Fangzhou; Zhang, Jinchao; Ou, Caiwen; Zhao, Yongxiang; Liu, Xiaoxuan; Liang, Xing-Jie

来源：Nature Communications, 2021, 12(1): 4964.

DOI：10.1038/s41467-021-25197-z

• CHECKPOINT BLOCKADE
• IMMUNOTHERAPY
• NANOPARTICLES
• ACTIVATION
• DELIVERY
• MECHANISM
• RESPONSES
• IMMUNITY
• THERAPY
• TLR7

Immunological adjuvants are essential for successful cancer vaccination. However, traditional adjuvants have some limitations, such as lack of controllability and induction of systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), which is composed of a hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation with near-infrared light, the LIA not only induces tumour cell lysis and tumour antigen release, but also promotes the structural transformation of 2-nitroimidazole containing dendrimer to 2-aminoimidazole containing dendrimer which can activate dendritic cells via the Toll-like receptor 7-mediated signaling pathway. The LIA efficiently inhibits both primary and abscopal tumour growth and induces strong antigen-specific immune memory effect to prevent tumour metastasis and recurrence in vivo. Furthermore, LIA localizes the immunological adjuvant effect at the tumour site. We demonstrate this light-activable immunological adjuvant offers a safe and potent platform for in situ cancer vaccination. @@@ Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tumor immune responses in preclinical cancer models.

• 单位
  中国科学院; 南方医科大学; 国家纳米科学中心; 中国科学院研究生院