Catalyst- and Oxidant-Free Electrochemical Regioselective Halogenation and Trifluoromethylation of 4H-Pyrido[1,2-a]pyrimidin-4-ones

作者：Su, Meiyun; Guo, Lina; Mao, Peiyu; Xiao, Meng; Liu, Wenjie^*; Wang, Shaohua^*

来源：European Journal of Organic Chemistry, 2023, 26(29).

DOI：10.1002/ejoc.202300268

• electrosynthesis
• halogenation
• synthetic methods
• regioselectivity
• trifluoromethylation

The catalyst-free electrochemical halogenation and trifluoromethylation of 4H-pyrido[1,2-a]pyrimidin-4-ones was realized under external-oxidant-free conditions. This strategy provides an easy and green access to functionalized new 4H-pyrido[1,2-a]pyrimidin-4-one derivatives with broad scope, good functional group tolerance and high regioselectivity.

• 单位
  广东药学院