Arthriniumsteroids A-D, four new steroids from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212

作者：Li, Jixing; Tao, Huaming; Lei, Xin-xin; Zhang, Han; Zhou, Xuefeng; Liu, Yonghong; Li, Yunqiu^*; Yang, Bin^*

来源：Steroids, 2021, 171: 108831.

DOI：10.1016/j.steroids.2021.108831

• Marine fungus
• Simplicillium lanosoniveum
• Steroids
• Arthriniumsteroid

Four new steroids derivatives, namely arthriniumsteroids A - D (1-4), together with two known compounds, were isolated from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212. Their structures were elucidated by spectroscopic analysis and by comparison with those reported in the literature. The absolute configuration of 2 was confirmed by single-crystal X-ray diffraction. In bioassay, all compounds showed weak inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells

• 单位
  中国科学院; 南方医科大学