Taberdines L and M, two new alkaloids from Tabernaemontana divaricata

作者：Han, Lingling; Huang, Kepu; Chen, Chen; Zhu, Wentao; Ma, Yehan; Hao, Xiaojiang; He, Hongping; Zhang, Yu^*

来源：NATURAL PRODUCT RESEARCH, 2022, 36(21): 5470-5475.

DOI：10.1080/14786419.2021.2015596

• Apocynaceae
• Tabernaemontana divaricata
• monoterpenoid indole alkaloids
• taberdine L
• taberdine M

Two new alkaloids, taberdines L (1) and M (2), together with six known alkaloids, were isolated from the twigs and leaves of Tabernaemontana divaricata. Taberdine L (1) represents the first optically active natural member of the allo iboga class of alkaloids with the ethyl side chain in a bridgehead position. Their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation. The in vitro cytotoxic activities of 1 and 2 against five human cancer cell lines were also evaluated.

• 单位
  y; 云南大学