科研之友
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摘要
After spinal cord injury (SCI), endogenous neural stem cells are activated and migrate to the injury site where they differentiate into astrocytes, but they rarely differentiate into neu-rons. It is difficult for brain-derived information to be transmitted through the injury site after SCI because of the lack of neurons that can relay neural information through the injury site, and the functional recovery of adult mammals is difficult to achieve. The development of bioactive materials, tissue engineering, stem cell therapy, and physiotherapy has provid-ed new strategies for the treatment of SCI and shown broad application prospects, such as promoting endogenous neurogenesis after SCI. In this review, we focus on novel approach-es including tissue engineering, stem cell technology, and physiotherapy to promote endog-enous neurogenesis and their therapeutic effects on SCI. Moreover, we explore the mecha-nisms and challenges of endogenous neurogenesis for the repair of SCI.
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单位汕头大学; 广东省心血管病研究所; 南方医科大学; 广东省人民医院; 中山大学
