An adhesive peptide specifically induces microtubule condensation

作者：Li, Yi-Jing; Wang, Jia-Qi; Tian, Wen; Han, Lu; Xiao, Ting; Wu, Xiu-Hai; Wang, Lei; Yang, Pei-Pei^*; Cao, Hui^*; Xu, Wan-Hai^*; Wang, Hao^*

来源：Materials Horizons, 2023, 10(11): 5298-5306.

DOI：10.1039/d3mh00867c

• TUBULIN
• RESISTANCE
• DRIVEN

Cell function-associated biomolecular condensation has great potential in modulation of molecular activities. We develop a microtubule-trapping peptide that first self-assembles into nanoparticles and then in situ transforms into nanofibers via ligand-receptor interactions when targeted to tubulin. The nanofibers support the increased exposed targets for further adhering to microtubules and induce the self-assembly of microtubules into networks due to multivalent effects. Microtubule condensation with prolonged retention in cells for up to 24 h, which is 6 times longer than that of the non-transformable nanoparticle group, efficiently induces in vitro cell apoptosis and inhibits in vivo tumour growth. These smart transformable peptide materials for targeted protein condensation have the potential for improving retention and inducing cell apoptosis in tumour therapy. @@@ Bimolecular condensation for modulation of biomolecular activity is a significant trend for cancer therapy. Peptide nanofibers target and bind to microtubules, forming hybrid network condensates, which induce cell apoptosis, and inhibit tumour growth.

• 单位
  中国科学院; 北京科技大学; 哈尔滨医科大学; 国家纳米科学中心